The Jewish presence probably dates back to Roman times. However, administrative records show a Jewish presence in Nis from the 17th century onwards. 800 Jews lived in Nis at the turn of the 20th century, working mainly in textiles, crafts and trade. The Shoah claimed many victims among the Jewish population of Nis and those who took refuge there during the war. By the 1950s, there were only around twenty Jews left in Nis, and the synagogue was converted into a concert hall.

A monument dedicated to the victims of the Shoah has been put up on Bubanj Hill. The former synagogue today serves as an art gallery, and the Jewish cemetery was rehabilitated in 2004.

Sources: Encyclopaedia Judaica