This charming little town situated above the Drava river was an important Roman military site which developed the town of Poetovium there. It was destroyed by the Huns in the 5th century and then rebuilt by the Slavs who settled there.

The Jewish presence in the town of Ptuj, best known today for its vineyards, probably dates from the end of the 13th century. The Provincial Museum also presents Jewish tombs from medieval times to the public.

The old Jewish street is now called Jadranska. The  synagogue appeared to be located according to research by historians at number 9 Jadranska Street. It was replaced by a church in 1441, which was transformed into an apartment building in 1840.